association of hepatitis virus on acute and chronic myeloid leukemias. a pilot study
نویسندگان
چکیده
background the induction ofâ cancers incidence by exogenous agents, such as chemical, radiation and especially research on viruses is an interestedâ area of active basic subjectsâ and clinical investigation. prominent researches sounds aâ high prevalence of hbv marker has been found in patients with leukemia as compared to the general population. methods: presentâ â study was conducted from 1996â to 2010â â â among patients with chronic acuteâ myeloid leukemia and corresponding with non malignant patients. in this investigation, â cytochemical staining, immunophenotyping, cytogenetic /molecular cytogenetics, elisa, enzyme immunoassay and western blot, were the main subject of laboratory manipulation. results: hepatitis b virus was diagnosedâ in one non malignant control patientâ (%0.004) and four infected with leukemia patients (%3). the differences ofâ leukemic patients revealed statistical significant when compared with non malignant patients ( p =0.0047). conclusion: in this pilot study, the prevalence of hbv infection was higher in patients with leukemiaâ than in patients as non malignant patients. our findings are also important as they are among the first to suggest here a potentially significant influence of â hbvâ infection may playsâ a probably major role in theâ processâ of myeloid malignantâ development. however, the number of cases are not large enough to draw firm conclusion. moreover, we suggest that this pilot study, issue warrants further investigation by large consortium project.
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عنوان ژورنال:
basic and clinical cancer researchجلد ۳، شماره ۳&۴، صفحات ۲-۶
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